Peer reviewed Scientific Studies Reference List

Here is a list of Peer reviewed Scientific Studies that have been published that relate to the health benefits of Wasabia japonica [Eutrema japonicum].

Browse at your leisure. All references have hyperlinks where you go the document itself to find the details of the study and the results they found.

More of these studies will be added as and when we find them. If you find any in your own research that isn't on this list then let us know and we will add them.

Mechanisms of action of isothiocyanates in cancer chemoprevention: an update

Navarro SL, Li F, Lampe JW. Mechanisms of action of isothiocyanates in cancer chemoprevention: an update. Food Funct. 2011 Oct;2(10):579-87. doi: 10.1039/c1fo10114e. Epub 2011 Sep 21. PMID: 21935537; PMCID: PMC3204939.

5-Hydroxyferulic acid methyl ester isolated from wasabi leaves inhibits 3T3-L1 adipocyte differentiation

Misawa N, Hosoya T, Yoshida S, Sugimoto O, Yamada-Kato T, Kumazawa S. 5-Hydroxyferulic acid methyl ester isolated from wasabi leaves inhibits 3T3-L1 adipocyte differentiation. Phytother Res. 2018 Jul;32(7):1304-1310. doi: 10.1002/ptr.6060. Epub 2018 Feb 26. PMID: 29480572.

Subchronic toxicity evaluation of 5-hexenyl isothiocyanate, a nature identical flavoring substance from Wasabia japonica, in F344/DuCrj rats

Yamaguchi M. The botanical molecule p-hydroxycinnamic acid as a new osteogenic agent: insight into the treatment of cancer bone metastases. Mol Cell Biochem. 2016 Oct;421(1-2):193-203. doi: 10.1007/s11010-016-2803-1. Epub 2016 Aug 30. PMID: 27573001.

The botanical molecule p-hydroxycinnamic acid as a new osteogenic agent: insight into the treatment of cancer bone metastases

The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia

Hashimoto K, Tashima K, Imai T, Matsumoto K, Horie S. The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia. J Pharmacol Sci. 2021 Jan;145(1):122-129. doi: 10.1016/j.jphs.2020.10.006. Epub 2020 Nov 11. PMID: 33357770.

Individual differences in the perception of orthonasal irritation induced by food

Piochi M, Cabrino G, Morini G, Torri L. Individual differences in the perception of orthonasal irritation induced by food. Appetite. 2020 Jan 1;144:104460. doi: 10.1016/j.appet.2019.104460. Epub 2019 Sep 16. PMID: 31536745.

Wasabi and a volatile anesthetic.

Gallos G, Flood P. Wasabi and a volatile anesthetic. Anesthesiology. 2010 Jun;112(6):1309-10. doi: 10.1097/ALN.0b013e3181d94e1b. PMID: 20502113.

Phytochemical profiling of five medicinally active constituents across 14 Eutrema species

Hao G, Wang Q, Liu B, Liu J. Phytochemical profiling of five medicinally active constituents across 14 Eutrema species. Fitoterapia. 2016 Apr;110:83-8. doi: 10.1016/j.fitote.2016.03.001. Epub 2016 Mar 3. PMID: 26946379.

Identification and Characterization of Apigenin 6-C-Glucosyltransferase Involved in Biosynthesis of Isosaponarin in Wasabi (Eutrema japonicum)

Mashima K, Hatano M, Suzuki H, Shimosaka M, Taguchi G. Identification and Characterization of Apigenin 6-C-Glucosyltransferase Involved in Biosynthesis of Isosaponarin in Wasabi (Eutrema japonicum). Plant Cell Physiol. 2019 Dec 1;60(12):2733-2743. doi: 10.1093/pcp/pcz164. PMID: 31418788.

Watch the Wasabe--revisited severe palmar hyperhidrosis treated with sympathotomy instead of sympathectomy

Goldstein N. Watch the Wasabe--revisited severe palmar hyperhidrosis treated with sympathotomy instead of sympathectomy. Hawaii Med J. 2003 Jul;62(7):140. PMID: 12971130.

Selective sensitivity to wasabi-derived 6-(methylsulfinyl)hexyl isothiocyanate of human breast cancer and melanoma cell lines studied in vitro

Nomura T, Shinoda S, Yamori T, Sawaki S, Nagata I, Ryoyama K, Fuke Y. Selective sensitivity to wasabi-derived 6-(methylsulfinyl)hexyl isothiocyanate of human breast cancer and melanoma cell lines studied in vitro. Cancer Detect Prev. 2005;29(2):155-60. doi: 10.1016/j.cdp.2004.07.010. PMID: 15829375.

Inhibitory effects of wasabi isothiocyanates on chemical mediator release in RBL-2H3 rat basophilic leukemia cells

Yamada-Kato T, Nagai M, Ohnishi M, Yoshida K. Inhibitory effects of wasabi isothiocyanates on chemical mediator release in RBL-2H3 rat basophilic leukemia cells. J Nutr Sci Vitaminol (Tokyo). 2012;58(4):303-7. doi: 10.3177/jnsv.58.303. PMID: 23132316.

A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction

Shibata T, Nakahara H, Kita N, Matsubara Y, Han C, Morimitsu Y, Iwamoto N, Kumagai Y, Nishida M, Kurose H, Aoki N, Ojika M, Uchida K. A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction. J Neurochem. 2008 Dec;107(5):1248-60. doi: 10.1111/j.1471-4159.2008.05686.x. Epub 2008 Oct 24. PMID: 18796006.

Improvement Effects of Wasabi (Wasabia japonica) Leaves and Allyl Isothiocyanate on Stomach Lesions of Mongolian Gerbils Infected with Helicobacter pylori

Masuda S, Masuda H, Shimamura Y, Sugiyama C, Takabayashi F. Improvement Effects of Wasabi (Wasabiajaponica) Leaves and Allyl Isothiocyanate on Stomach Lesions of Mongolian Gerbils Infected with Helicobacter pylori. Nat Prod Commun. 2017 Apr;12(4):595-598. PMID: 30520603.

A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway

Morimitsu Y, Nakagawa Y, Hayashi K, Fujii H, Kumagai T, Nakamura Y, Osawa T, Horio F, Itoh K, Iida K, Yamamoto M, Uchida K. A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J Biol Chem. 2002 Feb 1;277(5):3456-63. doi: 10.1074/jbc.M110244200. Epub 2001 Nov 12. PMID: 11706044.

Wasalexins A and B, new phytoalexins from wasabi: isolation, synthesis, and antifungal activity

Pedras MS, Sorensen JL, Okanga FI, Zaharia IL. Wasalexins A and B, new phytoalexins from wasabi: isolation, synthesis, and antifungal activity. Bioorg Med Chem Lett. 1999 Oct 18;9(20):3015-20. doi: 10.1016/s0960-894x(99)00523-5. PMID: 10571166.

DNA Microarray Profiling Highlights Nrf2-Mediated Chemoprevention Targeted by Wasabi-Derived Isothiocyanates in HepG2 Cells

Trio PZ, Kawahara A, Tanigawa S, Sakao K, Hou DX. DNA Microarray Profiling Highlights Nrf2-Mediated Chemoprevention Targeted by Wasabi-Derived Isothiocyanates in HepG2 Cells. Nutr Cancer. 2017 Jan;69(1):105-116. doi: 10.1080/01635581.2017.1248296. Epub 2016 Dec 2. PMID: 27911093.

Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs

Okonkwo A, Mitra J, Johnson GS, Li L, Dashwood WM, Hegde ML, Yue C, Dashwood RH, Rajendran P. Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs. Mol Nutr Food Res. 2018 Sep;62(18):e1800228. doi: 10.1002/mnfr.201800228. Epub 2018 Jul 19. PMID: 29924908; PMCID: PMC6553464.

In situ observation of the generation of isothiocyanates from sinigrin in horseradish and wasabi

Yu EY, Pickering IJ, George GN, Prince RC. In situ observation of the generation of isothiocyanates from sinigrin in horseradish and wasabi. Biochim Biophys Acta. 2001 Aug 15;1527(3):156-60. doi: 10.1016/s0304-4165(01)00161-1. PMID: 11479032.

Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activation of the Nrf2 transcription factor and selective cytotoxic activity

Elhalem E, Recio R, Werner S, Lieder F, Calderón-Montaño JM, López-Lázaro M, Fernández I, Khiar N. Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activation of the Nrf2 transcription factor and selective cytotoxic activity. Eur J Med Chem. 2014 Nov 24;87:552-63. doi: 10.1016/j.ejmech.2014.09.052. Epub 2014 Sep 16. PMID: 25299679.

Enzymic phenol oxidation. 3. Head-to-head coupling of 1,2,3,4-tetrahydro-7-hydroxy-1-(4-hydroxyphenethyl)-6-methoxy-2-methylisoquinoline with homogenised Wasabia japonica Matsumura and hydrogen peroxide

Kametani T, Takano S, Kobari T. Enzymic phenol oxidation. 3. Head-to-head coupling of 1,2,3,4-tetrahydro-7-hydroxy-1-(4-hydroxyphenethyl)-6-methoxy-2-methylisoquinoline with homogenised Wasabia japonica Matsumura and hydrogen peroxide. J Chem Soc Perkin 1. 1969;19:2770-3. doi: 10.1039/j39690002770. PMID: 5391239.

Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κB/TNF-α Signaling

Subedi L, Venkatesan R, Kim SY. Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κB/TNF-α Signaling. Int J Mol Sci. 2017 Jul 3;18(7):1423. doi: 10.3390/ijms18071423. PMID: 28671636; PMCID: PMC5535914.

Complete chloroplast genome sequence and phylogenetic analysis of wasabi (Eutrema japonicum) and its relatives

Haga N, Kobayashi M, Michiki N, Takano T, Baba F, Kobayashi K, Ohyanagi H, Ohgane J, Yano K, Yamane K. Complete chloroplast genome sequence and phylogenetic analysis of wasabi (Eutrema japonicum) and its relatives. Sci Rep. 2019 Oct 7;9(1):14377. doi: 10.1038/s41598-019-49667-z. PMID: 31591417; PMCID: PMC6779752

Individual differences in the perception of orthonasal irritation induced by food

Wasabi and a volatile anesthetic

Gallos G, Flood P. Wasabi and a volatile anesthetic. Anesthesiology. 2010 Jun;112(6):1309-10. doi: 10.1097/ALN.0b013e3181d94e1b. PMID: 20502113.

Takotsubo cardiomyopathy triggered by wasabi consumption: can sushi break your heart?

Finkel-Oron A, Olchowski J, Jotkowitz A, Barski L. Takotsubo cardiomyopathy triggered by wasabi consumption: can sushi break your heart? BMJ Case Rep. 2019 Sep 20;12(9):e230065. doi: 10.1136/bcr-2019-230065. PMID: 31540920; PMCID: PMC6768342.

16S rRNA-based amplicon analysis of changes in the bacterial population in the lesions of papillomatous digital dermatitis in dairy cattle after topical treatment with allyl isothiocyanate

Gotoh Y, Chiba K, Sekiyama Y, Okada K, Hayashi T, Misawa N. 16S rRNA-based amplicon analysis of changes in the bacterial population in the lesions of papillomatous digital dermatitis in dairy cattle after topical treatment with allyl isothiocyanate. Microbiol Immunol. 2020 Jun;64(6):416-423. doi: 10.1111/1348-0421.12786. Epub 2020 Apr 26. PMID: 32190917.

The effect of 6-methylthiohexyl isothiocyanate isolated from Wasabia japonica (wasabi) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-buatnone-induced lung tumorigenesis in mice

Yano T, Yajima S, Virgona N, Yano Y, Otani S, Kumagai H, Sakurai H, Kishimoto M, Ichikawa T. The effect of 6-methylthiohexyl isothiocyanate isolated from Wasabia japonica (wasabi) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-buatnone-induced lung tumorigenesis in mice. Cancer Lett. 2000 Jul 31;155(2):115-20. doi: 10.1016/s0304-3835(00)00364-5. PMID: 10822125.

Anti-obesity effects of hot water extract from Wasabi (Wasabia japonica Matsum.) leaves in mice fed high-fat diets

Yamasaki M, Ogawa T, Wang L, Katsube T, Yamasaki Y, Sun X, Shiwaku K. Anti-obesity effects of hot water extract from Wasabi (Wasabia japonica Matsum.) leaves in mice fed high-fat diets. Nutr Res Pract. 2013 Aug;7(4):267-72. doi: 10.4162/nrp.2013.7.4.267. Epub 2013 Aug 7. PMID: 23964313; PMCID: PMC3746160.

Administration of Wasabia koreana Ameliorates Irritable Bowel Syndrome-Like Symptoms in a Zymosan-Induced Mouse Model

Park BK, Chun E, Choi JJ, Shin Y, Kho YT, Oh SH, Kim SY, Lee TH, Kim TW, Shin E, Do SG, Jin M. Administration of Wasabia koreana Ameliorates Irritable Bowel Syndrome-Like Symptoms in a Zymosan-Induced Mouse Model. J Med Food. 2017 May;20(5):474-484. doi: 10.1089/jmf.2016.3844. Epub 2017 Apr 28. PMID: 28452565; PMCID: PMC5444489.

C-terminal domain of a hevein-like protein from Wasabia japonica has potent antimicrobial activity

Kiba A, Saitoh H, Nishihara M, Omiya K, Yamamura S. C-terminal domain of a hevein-like protein from Wasabia japonica has potent antimicrobial activity. Plant Cell Physiol. 2003 Mar;44(3):296-303. doi: 10.1093/pcp/pcg035. PMID: 12668776.

Molecular Mechanisms Underlying Anti-Inflammatory Actions of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica)

Uto T, Hou DX, Morinaga O, Shoyama Y. Molecular Mechanisms Underlying Anti-Inflammatory Actions of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica). Adv Pharmacol Sci. 2012;2012:614046. doi: 10.1155/2012/614046. Epub 2012 Aug 15. PMID: 22927840; PMCID: PMC3426159.

Anti-oxidant and Anti-hypercholesterolemic Activities of Wasabia japonica

Lee YS, Yang JH, Bae MJ, Yoo WK, Ye S, Xue CC, Li CG. Anti-oxidant and Anti-hypercholesterolemic Activities of Wasabia japonica. Evid Based Complement Alternat Med. 2010 Dec;7(4):459-64. doi: 10.1093/ecam/nen038. Epub 2008 Jun 12. PMID: 18955343; PMCID: PMC2892354.

Antioxidant phenylpropanoid glycosides from the leaves of Wasabia japonica

Hosoya T, Yun YS, Kunugi A. Antioxidant phenylpropanoid glycosides from the leaves of Wasabia japonica. Phytochemistry. 2008 Feb;69(3):827-32. doi: 10.1016/j.phytochem.2007.08.021. Epub 2007 Oct 24. PMID: 17920090.

Subchronic toxicity evaluation of 5-hexenyl isothiocyanate, a nature identical flavoring substance from Wasabia japonica, in F344/DuCrj rats

Akagi JI, Cho YM, Mizuta Y, Toyoda T, Ogawa K. Subchronic toxicity evaluation of 5-hexenyl isothiocyanate, a nature identical flavoring substance from Wasabia japonica, in F344/DuCrj rats. Food Chem Toxicol. 2018 Dec;122:80-86. doi: 10.1016/j.fct.2018.09.060. Epub 2018 Sep 25. PMID: 30266315.

Wasabi - Japanese Horseradish

Tamanna Sultana and Geoffrey P. Savage, Wasabi - Japanese Horseradish, Bangladesh J. Sci. Ind. Res. 43(4), 433-448, 2008

Wasabia japonica is a potential functional food to prevent colitis via inhibiting the NF-κB signaling pathway

Kang JH, Choi S, Jang JE, Ramalingam P, Ko YT, Kim SY, Oh SH. Wasabia japonica is a potential functional food to prevent colitis via inhibiting the NF-κB signaling pathway. Food Funct. 2017 Aug 1;8(8):2865-2874. doi: 10.1039/c7fo00576h. Epub 2017 Jul 20. PMID: 28726958.

Bactericidal activity of wasabi (Wasabia japonica) against Helicobacter pylori

Shin IS, Masuda H, Naohide K. Bactericidal activity of wasabi (Wasabia japonica) against Helicobacter pylori. Int J Food Microbiol. 2004 Aug 1;94(3):255-61. doi: 10.1016/S0168-1605(03)00297-6. PMID: 15246236.

The induction of apoptosis and autophagy by Wasabia japonica extract in colon cancer

Hsuan SW, Chyau CC, Hung HY, Chen JH, Chou FP. The induction of apoptosis and autophagy by Wasabia japonica extract in colon cancer. Eur J Nutr. 2016 Mar;55(2):491-503. doi: 10.1007/s00394-015-0866-5. Epub 2015 Feb 27. PMID: 25720497.

Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice

Choi BR, Kim HJ, Lee YJ, Ku SK. Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice. Nutrients. 2020 Sep 16;12(9):2837. doi: 10.3390/nu12092837. PMID: 32947952; PMCID: PMC7551095.

Leaf extract of Wasabia japonica relieved oxidative stress induced by Helicobacter pylori infection and stress loading in Mongolian gerbils

Sekiguchi H, Takabayashi F, Deguchi Y, Masuda H, Toyoizumi T, Masuda S, Kinae N. Leaf extract of Wasabia japonica relieved oxidative stress induced by Helicobacter pylori infection and stress loading in Mongolian gerbils. Biosci Biotechnol Biochem. 2010;74(6):1194-9. doi: 10.1271/bbb.90919. Epub 2010 Jun 7. PMID: 20530903.

Isothiocyanates from Wasabia japonica activate transient receptor potential ankyrin 1 channel

Uchida K, Miura Y, Nagai M, Tominaga M. Isothiocyanates from Wasabia japonica activate transient receptor potential ankyrin 1 channel. Chem Senses. 2012 Nov;37(9):809-18. doi: 10.1093/chemse/bjs065. Epub 2012 Aug 6. PMID: 22869685.

Wasabi Compound 6-(Methylsulfinyl) Hexyl Isothiocyanate Induces Cell Death with Coexisting Mitotic Arrest and Autophagy in Human Chronic Myelogenous Leukemia K562 Cells

Wu KM, Liao HF, Chi CW, Kou YR, Chen YJ. Wasabi Compound 6-(Methylsulfinyl) Hexyl Isothiocyanate Induces Cell Death with Coexisting Mitotic Arrest and Autophagy in Human Chronic Myelogenous Leukemia K562 Cells. Biomolecules. 2019 Nov 23;9(12):774. doi: 10.3390/biom9120774. PMID: 31771225; PMCID: PMC6995613.

Wasabi 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human colorectal cancer cells through p53-independent mitochondrial dysfunction pathway

Yano S, Wu S, Sakao K, Hou DX. Wasabi 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human colorectal cancer cells through p53-independent mitochondrial dysfunction pathway. Biofactors. 2018 May 14. doi: 10.1002/biof.1431. Epub ahead of print. PMID: 29756671.

Effect of Wasabi Component 6-(Methylsulfinyl)hexyl Isothiocyanate and Derivatives on Human Pancreatic Cancer Cells

Chen YJ, Huang YC, Tsai TH, Liao HF. Effect of Wasabi Component 6-(Methylsulfinyl)hexyl Isothiocyanate and Derivatives on Human Pancreatic Cancer Cells. Evid Based Complement Alternat Med. 2014;2014:494739. doi: 10.1155/2014/494739. Epub 2014 Jan 20. PMID: 24575144; PMCID: PMC3918374.

Colon cancer proliferating desulfosinigrin in wasabi (Wasabia japonica)

Weil MJ, Zhang Y, Nair MG. Colon cancer proliferating desulfosinigrin in wasabi (Wasabia japonica). Nutr Cancer. 2004;48(2):207-13. doi: 10.1207/s15327914nc4802_11. PMID: 15231456.

Molecular Mechanisms Underlying Anti-Inflammatory Actions of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica)

5-Hydroxyferulic acid methyl ester isolated from wasabi leaves inhibits 3T3-L1 adipocyte differentiation

Tumor cell proliferation and cyclooxygenase inhibitory constituents in horseradish (Armoracia rusticana) and Wasabi (Wasabia japonica)

Weil MJ, Zhang Y, Nair MG. Tumor cell proliferation and cyclooxygenase inhibitory constituents in horseradish (Armoracia rusticana) and Wasabi (Wasabia japonica). J Agric Food Chem. 2005 Mar 9;53(5):1440-4. doi: 10.1021/jf048264i. PMID: 15740020.

Rare Thioglycosides from the Roots of Wasabia japonica

Kim CS, Oh J, Subedi L, Kim SY, Choi SU, Lee KR. Rare Thioglycosides from the Roots of Wasabia japonica. J Nat Prod. 2018 Sep 28;81(9):2129-2133. doi: 10.1021/acs.jnatprod.8b00570. Epub 2018 Sep 20. PMID: 30232882.

Allyl Isothiocyanate Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mouse by Enhancing Tight Junction and Mucin Expression

Kim MW, Choi S, Kim SY, Yoon YS, Kang JH, Oh SH. Allyl Isothiocyanate Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mouse by Enhancing Tight Junction and Mucin Expression. Int J Mol Sci. 2018 Jul 12;19(7):2025. doi: 10.3390/ijms19072025. PMID: 30002285; PMCID: PMC6073867.

Glycogen synthase kinase-3β inhibition of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum)

Yoshida J, Nomura S, Nishizawa N, Ito Y, Kimura K. Glycogen synthase kinase-3β inhibition of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum). Biosci Biotechnol Biochem. 2011;75(1):136-9. doi: 10.1271/bbb.100507. Epub 2011 Jan 7. PMID: 21228474.

Glycogen synthase kinase-3β inhibition of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum)

[Studies on the volatile components of Wasabia japonica, Brassica juncea and Cocholearia armoracia by gas chromatography-mass spectrometry. I. Determination of low mass volatile components]

Kojima M, Uchida M, Akahori Y. [Studies on the volatile components of Wasabia japonica, Brassica juncea and Cocholearia armoracia by gas chromatography-mass spectrometry. I. Determination of low mass volatile components]. Yakugaku Zasshi. 1973 Apr;93(4):453-9. Japanese. doi: 10.1248/yakushi1947.93.4_453. PMID: 4738516.

Functional properties of wasabi and horseradish

Kinae N, Masuda H, Shin IS, Furugori M, Shimoi K. Functional properties of wasabi and horseradish. Biofactors. 2000;13(1-4):265-9. doi: 10.1002/biof.5520130140. PMID: 11237192.

Wasabi leaf extracts attenuate adipocyte hypertrophy through PPARγ and AMPK

Oowatari Y, Ogawa T, Katsube T, Iinuma K, Yoshitomi H, Gao M. Wasabi leaf extracts attenuate adipocyte hypertrophy through PPARγ and AMPK. Biosci Biotechnol Biochem. 2016 Aug;80(8):1594-601. doi: 10.1080/09168451.2016.1179093. Epub 2016 May 3. PMID: 27140496.

Glycogen synthase kinase-3β inhibition of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum)

Wasabi 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human colorectal cancer cells through p53-independent mitochondrial dysfunction pathway

6-(Methylsulfinyl)hexyl isothiocyanate protects acetaldehyde-caused cytotoxicity through the induction of aldehyde dehydrogenase in hepatocytes

Kitakaze T, Yuan S, Inoue M, Yoshioka Y, Yamashita Y, Ashida H. 6-(Methylsulfinyl)hexyl isothiocyanate protects acetaldehyde-caused cytotoxicity through the induction of aldehyde dehydrogenase in hepatocytes. Arch Biochem Biophys. 2020 Jun 15;686:108329. doi: 10.1016/j.abb.2020.108329. Epub 2020 Mar 7. PMID: 32151565.

6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) from Wasabia japonica alleviates inflammatory bowel disease (IBD) by potential inhibition of glycogen synthase kinase 3 beta (GSK-3β)

Lohning A, Kidachi Y, Kamiie K, Sasaki K, Ryoyama K, Yamaguchi H. 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) from Wasabia japonica alleviates inflammatory bowel disease (IBD) by potential inhibition of glycogen synthase kinase 3 beta (GSK-3β). Eur J Med Chem. 2021 Apr 15;216:113250. doi: 10.1016/j.ejmech.2021.113250. Epub 2021 Feb 13. PMID: 33691258.

Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabia japonica

LMorimitsu Y, Hayashi K, Nakagawa Y, Fujii H, Horio F, Uchida K, Osawa T. Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi. Mech Ageing Dev. 2000 Jul 31;116(2-3):125-34. doi: 10.1016/s0047-6374(00)00114-7. PMID: 10996012.

Synergistic effect of active oxygen species and alginate on chitinase production by Wasabia japonica cells and its application

Akimoto C, Aoyagi H, Dicosmo F, Tanaka H. Synergistic effect of active oxygen species and alginate on chitinase production by Wasabia japonica cells and its application. J Biosci Bioeng. 2000;89(2):131-7. doi: 10.1016/s1389-1723(00)88726-5. PMID: 16232715.

Wasabisides A-E, Lignan Glycosides from the Roots of Wasabia japonica

Kim CS, Subedi L, Kwon OW, Park HB, Kim SY, Choi SU, Lee KR. Wasabisides A-E, Lignan Glycosides from the Roots of Wasabia japonica. J Nat Prod. 2016 Oct 28;79(10):2652-2657. doi: 10.1021/acs.jnatprod.6b00582. Epub 2016 Oct 4. PMID: 27700070.

Investigation of total phenolic, total flavonoid, antioxidant and allyl isothiocyanate content in the different organs of Wasabia japonica grown in an organic system

Shin SW, Ghimeray AK, Park CH. Investigation of total phenolic, total flavonoid, antioxidant and allyl isothiocyanate content in the different organs of Wasabi japonica grown in an organic system. Afr J Tradit Complement Altern Med. 2014 Apr 3;11(3):38-45. doi: 10.4314/ajtcam.v11i3.7. PMID: 25371562; PMCID: PMC4202418.

6-Methylsulfinylhexyl isothiocyanate modulates endothelial cell function and suppresses leukocyte adhesion

Okamoto T, Akita N, Nagai M, Hayashi T, Suzuki K. 6-Methylsulfinylhexyl isothiocyanate modulates endothelial cell function and suppresses leukocyte adhesion. J Nat Med. 2014 Jan;68(1):144-53. doi: 10.1007/s11418-013-0784-x. Epub 2013 Jun 12. PMID: 23760613.

DNA Microarray Highlights Nrf2-Mediated Neuron Protection Targeted by Wasabi-Derived Isothiocyanates in IMR-32 Cells

Trio PZ, Fujisaki S, Tanigawa S, Hisanaga A, Sakao K, Hou DX. DNA Microarray Highlights Nrf2-Mediated Neuron Protection Targeted by Wasabi-Derived Isothiocyanates in IMR-32 Cells. Gene Regul Syst Bio. 2016;10:73-83. Published 2016 Aug 11. doi:10.4137/GRSB.S39440

Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-gamma and 12-O-tetradecanoylphorbol-13-acetate

Uto T, Fujii M, Hou DX. Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-gamma and 12-O-tetradecanoylphorbol-13-acetate. Oncol Rep. 2007 Jan;17(1):233-8. PMID: 17143503.

Comparison of isothiocyanate yield from wasabi rhizome tissues grown in soil or water

Sultana T, Porter NG, Savage GP, McNeil DL. Comparison of isothiocyanate yield from wasabi rhizome tissues grown in soil or water. J Agric Food Chem. 2003 Jun 4;51(12):3586-91. doi: 10.1021/jf021116c. PMID: 12769529.

Bioactive Immunomodulatory Compounds: A Novel Combinatorial Strategy for Integrated Medicine in Oncology? BAIC Exposure in Cancer Cells

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Wasabia koreana Nakai: A Preliminary Study on Nutrients and Chemical Compounds That May Impact Sensory Properties

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The induction of apoptosis and autophagy by Wasabia japonica extract in colon cancer

The effect of isosaponarin isolated from wasabi leaf on collagen synthesis in human fibroblasts and its underlying mechanism

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ERK-modulated intrinsic signaling and G(2)/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells

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